It is the creed of what makes America and now, what makes the aspirations of many people around the world.
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Even though they mean "man" sort of like mankind, they also really generally mean men, at this point. First of all, it doesn't mean that people are always equal.
Once again, this is where the American narrative starts. At a certain point in life, Jefferson owns a whole lot of property and Franklin is quite rich as a printer and different people have different statuses in life, but they're saying that in a fundamental, political way, we all start off created equal.